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Nancy L. Ford

BSc, PhD
Assistant Professor
Director, Centre for High-Throughput Phenogenomics
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Research


Office:
Rm: Pharm Sci B211
Tel: 604-822-6641
Fax: 604-822-3562

Lab:
Rm: Pharm Sci B210


Research Areas:

Micro-computed tomography, x-ray imaging, physiological gating, small animal imaging, image quality, CBCT

Teaching Areas:

Radiology, Graduate student research supervision


Dr. Ford completed her BSc in Chemical Physics in 1997 (University of Waterloo) and PhD in Medical Biophysics in 2005 (University of Western Ontario). Her research experience includes working as a Research Assistant in a Digital Mammography research group at Sunnybrook Hospital in Toronto ON, and a postdoctoral fellowship in the Imaging Research Labs at the Robarts Research Institute in London ON. From 2006 to 2011, she was an Assistant Professor in the Department of Physics at Ryerson University. Her research experience in the technical aspects of clinical and pre-clinical medical imaging (primarily x-ray) will enable multidisciplinary studies at the Centre for High-Throughput Phenogenomics. 
 
Specialization: Micro-computed tomography; x-ray imaging; physiological gating; image quality metrics; pre-clinical imaging; dental radiology; dental CBCT; synchrotron imaging 
 
Preclinical Research Projects: 
Micro-computed tomography is a 3D x-ray imaging technique for producing high-resolution images of rodent anatomy. We have developed techniques for synchronizing the imaging acquisition protocol to the respiratory and cardiac rates of rodents. Synchronizing the imaging protocol allows us to produce images of a specific phase in the respiratory or cardiac cycle, and can produce a series of images throughout the cycle. These images can be analyzed to quantitatively study the anatomy and function of the rodents' heart or lungs. 
 
My current research involves optimizing the image acquisition techniques for small animal imaging using micro-computed tomography. Current projects include: 
 
A) Preclinical respiratory-gated micro-CT imaging in rodent models of chronic obstructive pulmonary disease (COPD). 
We are using respiratory-gated micro-CT to investigate the effects of cigarette-smoking in preclinical models. Since micro-CT is a non-invasive technique, we can visualize the structures within the breathing lung at different timepoints in the smoking exposure and determine how the lung structure and pulmonary vasculature are affected by the smoke exposure.  
Funding: BC Lung Association 
 
B) Contrast agent assessment for correlative imaging across different preclinical and specimen imaging modalities (micro-CT, optical projection tomography, etc.). 
We are developing techniques to image contrast media with different imaging modalities (x-ray and optical). Using a single contrast media will ensure that the same structures are highlighted in each of the images. 
Funding: NSERC Discovery Grant 
 
Clinical Research Projects: 
I am also interested in optimizing image quality in clinical CT imaging studies. Current projects with clinical collaborators include image quality assessment and optimization of cone-beam CT for dental applications and dosimetry for panoramic imaging. My research team has measured the x-ray dose from a range of x-ray imaging modalities relevant to dentistry, including head CT, panoramic, and cone beam CT (large and small fields of view). We applied a new measurement metric (AAPM Report 111) to provide an accurate comparison between modalities, and found that the dose delivered in dental CBCT may be higher than previously reported. We have also developed phantoms to represent the child and adolescent populations and have quantified how much additional dose is imparted to these patients compared with adults during the same imaging procedure. We are characterizing the image quality achieved using different imaging settings for different models of dental CBCT machines. 
 
My current research involves optimizing the image acquisition techniques for dental cone-beam computed tomography. Current projects include: 
 
A) Optimization of image quality for implant planning. 
We are measuring the image quality, using a set of objectives metrics, and the x-ray dose delivered for a variety of imaging conditions available on our dental CBCT scanner for a commonly used field of view in implant planning. In addition, we have done an image assessment for the diagnostic value of images obtained under the same variety of imaging conditions. From this information, we can identify the optimal settings to provide high-quality images, with excellent diagnostic value, at a low dose to the patient. 
 
B) Calibration of dental CBCT images into HU. 
Mulit-slice CT scanners in the hospital are calibrated so that images from all scanners produce images with similar properties, enabling the use of automated image processing algorithms. We are characterizing and calibrating dental CBCT units to provide images that are calibrated in the same way, enabling the dental profession to access a variety of validated tools for image segmentation and analysis. 
 
Available Positions: 
I am looking to accept students at the MSc, PhD or Postdoctoral level. Students may register in the Craniofacial Science program (Faculty of Dentistry), Experimental Medicine program (Faculty of Medicine), Biomedical Engineering (Faculty of Applied Science) or through the CAMPEP-accredited Medical Physics program (Faculty of Science). 
 
I also accept Biomedical Engineering students for BMEG 597 internships and strong undergraduate students for 4th year thesis projects, directed studies projects or paid positions (Work-Learn, Co-op, summer students). 
 
Selected Recent Publications: 
 
Books & Book Chapters: 
Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications 
Edited by: George C. Kagadis, Nancy L. Ford, Dimitrios N. Karnabatidis, George K. Loudos; 2016; CRC Press, Taylor & Francis Group 
Ford NL, Loudos GK, Karnabatidis D, Kagadis GC, “Chapter 1: Defining Small Animal Imaging, Therapy and Applications”.  
Ford NL, "Chapter 5: Micro-CT imaging".  
Ford NL, "Chapter 23: Performance Assessment of Small Animal Imaging Systems and Common Standards".  
 
Clinical Medical & Dental Imaging: 
Li CL, Thakur Y, Ford NL, “Comparison between CTDI and the AAPM Report No. 111 methodology in adult, adolescent, and child head phantoms for MSCT and dental CBCT scanners”, JOURNAL OF MEDICAL IMAGING (2017) 4(3) 031212, DOI: 10.1117/1.JMI.4.3.031212 
 
Wahid, M.A., E. Choi, D. MacDonald and N.L. Ford. “Dosimetry Analysis of Panoramic- Imaging Devices in Different-Sized Phantoms”, JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS (2017), 18(2):197-205; DOI:10.1002/acm2.12059 
 
Schroeder, A., N.L. Ford, J. Coil, "Micro-Computed Tomography Analysis Of Post Space Preparation In Teeth Obturated With Carrier-Based Thermoplasticized Gutta Percha Techniques", INTERNATIONAL ENDODONTIC JOURNAL. (2017) 50(3): 293-302; doi:10.1111/iej.12618  
 
Sonya, D.A., J. Davies and N.L. Ford. "A comparison of CBCT image quality obtained with different fields of view, voxel spacing and angular sampling for iCAT NG", JOURNAL OF ORAL AND MAXILLOFACIAL RADIOLOGY (2016) 4(2):31-39. DOI: 10.4103/2321-3841.183821 
 
Mendelsohn, D., J. Strelzow, N. Dea, N.L. Ford, J. Batke, M. Dvorak, C. Fisher, J. Street, "Patient and Surgeon Radiation Exposure during Spinal Instrumentation using Intraoperative CT-Based Navigation", THE SPINE JOURNAL, (2016) 16(3):343-354. doi: 10.1016/j.spinee.2015.11.020. 
 
Abouei, E., Lee, S., N.L. Ford, "Image quality and dose measurement for partial cone-beam CT", JOURNAL OF MEDICAL IMAGING. (2015) 2(4), 044002 doi: 10.1117/1.JMI.2.4.044002  
 
Choi E and Ford NL. " Measuring Absorbed Dose for i-CAT CBCT Exams in Child, Adolescent and Adult Phantoms", DENTOMAXILLOFACIAL RADIOLOGY. (2015) 44: 20150018 
 
Deman P, Atwal P, Duzenli C, Thakur Y, Ford NL. "Dose measurements for dental cone-beam CT: a comparison with MSCT and panoramic imaging", PHYSICS IN MEDICINE & BIOLOGY (2014) 59(12): 3201-3222. 
 
 
Preclinical imaging: 
Deman P, Tan S, Belev G, Samadi N, Martinson M, Chapman D, Ford NL, “Respiratory-gated KES imaging of rat model of acute lung injury”, JOURNAL OF SYNCHROTRON RADIATION (2017) 24(3), DOI: 10.1107/S160057751700193X 
 
Ford NL, McCaig L, Jeklin A, Lewis JF, Veldhuizen RAW, Holdsworth DW, Drangova M, “A respiratory-gated micro-CT comparison of respiratory patterns in free-breathing and mechanically ventilated rats”, PHYSIOLOGICAL REPORTS (2017) 5:2 DOI:10.14814/phy2.13074 
 
Jaw JE, Tsuruta M, Suda K, Oh Y, Schipilow J, Hirano Y, Ngan DA, Suda K, Li Y, Oh JY, Tam S, Ford NL, van Eeden S, Wright J, Man SFP, Sin DD, "Inflammation with Lipopolysaccharide Causes Atheroma Destabilisation", EUROPEAN RESPIRATORY JOURNAL (2016) 48: 205-215. DOI: 10.1183/13993003.00972-2015  
 
Karimi, D., P. Deman, R.K. Ward, N.L. Ford, "A Sinogram Denoising Algorithm for Low-Dose Computed Tomography", BMC MEDICAL IMAGING (2016) 16:11 DOI: 10.1186/s12880-016-0112-5 
 
Wiebe, S., T. W. Wysokinski, G. Belev, D. Miller, A. Webb, N. Zhu, D. Cooper, Z. Izadifar, A. Panahifar, N. Samadi, M. Martinson, N.L. Ford, P. Deman, X. Luan, J.P. Ianowski, D. Chen, D. Chapman, "Bio-Medical Imaging Using Synchrotron Radiation - The Experience of the BioMedical Imaging and Therapy (BMIT) Facility at the Canadian Light Source", SYNCHROTRON RADIATION NEWS. (2015) 28(5):16-23. 
 
 
Full Publication List