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Apical preparation assumes a key role in successful therapy of apical periodontitis, because it is the bacteria, particularly in this area of the root canal, that are responsible for the development of the periapical lesion. The technical goal of treatment of apical periodontitis is to reach the apical constriction and all regions of the root canal system with preparation instruments, intracanal medicaments and the root filling. If this can be done successfully, prognosis of the therapy is good. Variations in apical root canal morphology, however, may complicate treatment, as in the case of an apical delta, which may offer areas of concealment for micro-organisms. Details of apical root canal morphology often cannot be seen in radiographs.