Copious amount of sodium hypochlorite are used for irrigation, EDTA is used to remove the smear layer just before root filling.
Calcium hydroxide is used as an interappointment medicament in the canal for three reasons: 1) to eliminate residual bacteria in the coronal canal, 2) for its anti-inflammatory effect, 3) to necrotise the resorptive tissue to facilitate its removal by hypochlorite rinsing at the next appointment.